The Pennsylvania Geriatrics Society is thrilled to reconvene for the 34th Annual Clinical Update in Geriatric Medicine—an energizing opportunity to reconnect, share best practices, and learn together through the Age-Friendly 5Ms framework: Medication, Mentation, Mobility, Multicomplexity, and What Matters Most. The fastest growing segment of the population comprises individuals over the age of 85. The purpose of this annual conference is to provide an evidence-based approach to help clinicians take exceptional care of these often frail individuals.